When it comes to skincare routines, the question of whether cannabis-infused SPF can be used with other topical creams often arises. The short answer is yes—most cannabis SPF products, which are sunscreens formulated with CBD or other non-psychoactive cannabinoids, can be layered with other skincare items as long as they’re applied in the correct order.

Dermatologists generally recommend applying products from thinnest to thickest consistency: serums first, moisturizer second, and sunscreen last. This layering method ensures that sunscreen forms a continuous and protective film on the skin’s surface. Applying cannabis SPF as the final step in the daytime skincare routine helps maintain its UV defense while allowing cannabinoids to deliver their soothing and antioxidant benefits.

For the best results, users should consider “what goes under” and “what goes over.” Lightweight, water-based serums or moisturizers can be applied underneath cannabis SPF without interfering with its protection, provided each layer has time to absorb before the next is added. This approach helps prevent pilling and ensures the sunscreen spreads evenly across the skin.

When it comes to makeup or moisturizers that also contain SPF, it’s important to remember that layering products with different SPF values does not combine their levels of protection. The highest single SPF value remains the one that determines your true coverage. Using makeup with SPF can, however, provide supplemental protection in areas that are often missed.

A few exceptions and cautions should be noted:

• Avoid heavy occlusives before sunscreen. Thick ointments or oils can disrupt the sunscreen’s ability to adhere evenly, potentially reducing coverage. These products are better suited for nighttime routines or post-sun recovery.
• Separate acne treatments. Ingredients like benzoyl peroxide can cause irritation or destabilize other products if layered under sunscreen. These are best reserved for nighttime use.
• Follow water-resistance directions. Even with cannabis-infused SPF, only products tested for water resistance can guarantee protection during swimming or sweating. Reapplication every two hours—or immediately after water exposure—is key.

Cannabinoids such as CBD are known for their anti-inflammatory and antioxidant properties, which may complement the UV defense of sunscreen by supporting the skin barrier and reducing post-sun redness. However, these benefits do not replace the need for broad-spectrum UV filters, which remain the cornerstone of sun protection. Because cannabis-derived ingredients in cosmetics are not regulated by the FDA, consumers should purchase from reputable brands that provide testing transparency and ingredient clarity.

In summary: Cannabis SPF can be safely used with most other topical creams if applied in the correct order and given adequate time to absorb. Sunscreen should always be the last step before makeup to ensure an even protective film and optimal results.